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Overview
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This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
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- Properties
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Overview
Immunofluorescence analysis of MCF7 cells using Caspase-14 antibody (STJ28624). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using Caspase-14 antibody (STJ28624) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 30s.
Anti-CASP14 antibody
Anti-CASP14 antibody
Catalog Number:
A001036704STJ
Mfr. No.:
STJ28624
Price:
$297
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