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Overview
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Cardiotin is a high molecular weight protein complex (300 kDa) located in the mitochondria ofcardiomyocytes and skeletal muscle. The cardiotin structure exists of subunits of 60 kDa and 100 kDa, probably in a tetrameric configuration. Both subunits contain the same amino-terminal 14 amino-acidsequence, showing high homology to Human skeletal muscle alpha-actinin. During cardiac contractiledysfunction and myocard cell differentiation, the cardiotin distribution is affected. Compared to otherstructural proteins, cardiotin is one of the first to respond to insults (ischemia, fibrillation) that influencethe functional status of cardiomyocytes.Immunogen: 100 kDa cardiotin subunit.
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