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Overview
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This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
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Overview
Immunohistochemistry of paraffin-embedded human stomach using BEST1 antibody (STJ111168) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat brain using BEST1 antibody (STJ111168) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver damage using BEST1 antibody (STJ111168) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using BEST1 antibody (STJ111168) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-BEST1 antibody
Anti-BEST1 antibody
Catalog Number:
A001019036STJ
Mfr. No.:
STJ111168
Price:
$297
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