Name: Anti-BCL10 antibody
Price: 295.00 USD

Overview
- This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human BCL10 (NP_003912. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  B-Cell Lymphoma/Leukemia 10; B-Cell Cll/Lymphoma 10; Bcl-10; Card-Containing Molecule Enhancing Nf-Kappa-B; Card-Like Apoptotic Protein; Hclap; Ced-3/Ich-1 Prodomain Homologous E10-Like Regulator; Ciper; Cellular Homolog Of Vcarmen; Ccarmen; Cellular-E10; C-E10; Mammalian Card-Containing Adapter Molecule E10; Me10 (Gene ID:8915; UniProt:O95999)
  
  * For research use only