Anti-BAP1 antibody

Catalog Number:
STJ28616
Price:
$874
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      • Overview
        • This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

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      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          Recombinant funsion protein containing a sequence corresponding to amino acids 460-729 of human BAP1 (NP_004647. 1).
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
          Storage
          Store at -20°C and avoid freeze-thaw cycles.
          Regulatory Status
          RUO
          Antigen
          Ubiquitin Carboxyl-Terminal Hydrolase Bap1; Brca1-Associated Protein 1; Cerebral Protein 6 (Gene ID:8314; UniProt:Q92560)

          * For research use only

      • Applications
        • Application
          WB; IF
        • Application Dilutions
          WB 1:500-1:2000
          IF 1:50-1:200
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