Name: Anti-Bad antibody
Price: 224.00 USD

Overview
- Bad is a protein encoded by the BAD gene which is approximately 18, 4 kDa. Bad is localised to the mitochondrion outer membrane and cytoplasm. It is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways, glioma and the development HGF signalling pathway. It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. It also appears to act as a link between growth factor receptor signalling and the apoptotic pathways. Bad is widely expressed in a wide variety of tissues. Mutations in the BAD gene may result in adrenal cortical adenocarcinoma and endometrial cancer. STJ91797 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bad protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Synthesized peptide derived from human Bad around the non-phosphorylation site of S91.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Bcl2-Associated Agonist Of Cell Death; Bad; Bcl-2-Binding Component 6; Bcl-2-Like Protein 8; Bcl2-L-8; Bcl-Xl/Bcl-2-Associated Death Promoter; Bcl2 Antagonist Of Cell Death (Gene ID:572; UniProt:Q92934)
  
  * For research use only