Anti-APP antibody

Catalog Number:

A001020455STJ

Mfr. No.:

STJ112892

Price:

$297

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Overview
- This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  A synthetic peptide of human APP
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Amyloid-Beta Precursor Protein; App; Abpp; Appi; Alzheimer Disease Amyloid Protein; Amyloid Precursor Protein; Amyloid-Beta A4 Protein; Cerebral Vascular Amyloid Peptide; Cvap; Prea4; Protease Nexin-II; Pn-II Cleaved Into-N-App-Soluble App-Alpha; S-App-Alpha-Soluble App-Beta; S-App-Beta-C99; Beta-Secretase C-Terminal Fragment; Beta-Ctf-Amyloid-Beta Protein 42; Abeta42; Beta-App42-Amyloid-Beta Protein 40; Abeta40; Beta-App40-C83; Alpha-Secretase C-Terminal Fragment; Alpha-Ctf-P3(42-P3(40-C80-Gamma-Secretase C-Terminal Fragment 59; Amyloid Intracellular Domain 59; Aicd-59; Aid(59; Gamma-Ctf(59-Gamma-Secretase C-Terminal Fragment 57; Amyloid Intracellular Domain 57; Aicd-57; Aid(57; Gamma-Ctf(57-Gamma-Secretase C-Terminal Fragment 50; Amyloid Intracellular Domain 50; Aicd-50; Aid(50; Gamma-Ctf(50-C31 (Gene ID:351; UniProt:P05067)
  
  * For research use only