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Overview
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ApoE is a protein encoded by the APOE gene which is approximately 36, 1 kDa. ApoE is secreted and is involved in lipoprotein metabolism, the statin pathway, respiratory electron transport and glucose/energy metabolism. It is a major apoprotein of chylomicrons. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE is expressed in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle. Mutations in the APOE gene may result in hyperlipoproteinemian. STJ91638 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of ApoE protein.
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Overview