Name: Anti-FAS antibody
Price: 224.00 USD

Overview
- FAS is a protein encoded by the FAS gene which is approximately 37, 7 kDa. FAS isoform 1 is localised to the cell membrane with other isoforms being secreted. It is involved in dimerization of procaspase-8, allograft rejection, apoptosis modulation and signalling, PEDF induced signalling and the TNFR1 pathway. This protein falls under the TNF-receptor superfamily. This receptor contains a death domain and plays a central role in the physiological regulation of programmed cell death, it has also been implicated in the pathogenesis of various malignancies and diseases of the immune system. FAS isoform 1 and 6 is expressed in resting peripheral blood mononuclear cells. Mutations in the FAS gene may result in autoimmune lymphoproliferative syndrome. STJ93041 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of FAS protein.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Synthesized peptide derived from human FAS around the non-phosphorylation site of Y291.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD antigen CD95 (Gene ID:355; UniProt:P25445)
  
  * For research use only

Applications

Application

WB; IF; ELISA

Application	Dilutions
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:10000

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Western blot analysis of lysates from 293 cells, using FAS Antibody. The lane on the right is blocked with the synthesized peptide.

Immunohistochemical analysis of paraffin-embedded Human testis. 1, Antibody was diluted at 1:100 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Immunofluorescence analysis of HeLa cells, using FAS Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-FAS antibody

Anti-FAS antibody