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Overview
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This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
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Overview
Immunofluorescence analysis of A431 cells using ACVR2A antibody (STJ22506) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded mouse brain using ACVR2A antibody (STJ22506) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using ACVR2A antibody (STJ22506) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophageal cancer using ACVR2A antibody (STJ22506) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using ACVR2A antibody (STJ22506) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 30s.
Anti-ACVR2A antibody
Anti-ACVR2A antibody
Catalog Number:
A001033244STJ
Mfr. No.:
STJ22506
Price:
$297
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