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Overview
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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
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Overview
Immunohistochemistry of paraffin-embedded mouse heart using ACTN1 antibody (STJ22500) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using ACTN1 antibody (STJ22500) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using ACTN1 antibody (STJ22500) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using ACTN1 antibody (STJ22500) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Anti-ACTN1 antibody
Anti-ACTN1 antibody
Catalog Number:
A001033239STJ
Mfr. No.:
STJ22500
Price:
$297
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