Name: Anti-ABCG2 antibody
Price: 297.00 USD

Overview
- The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 260-395 of human ABCG2 (NP_004818. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2; Atp-Binding Cassette Sub-Family G Member 2; Breast Cancer Resistance Protein; Cdw338; Mitoxantrone Resistance-Associated Protein; Placenta-Specific Atp-Binding Cassette Transporter; Urate Exporter; Cd Antigen Cd338 (Gene ID:9429; UniProt:Q9UNQ0)
  
  * For research use only