Name: Ansamitocin P-3
Price: 292.00 USD

- Overview
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    Background
    
    Ansamitocin P-3, a natural product, is maytansinoid which showed potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29 with ED50 of 4 x 10 -7, 4 x 10 – 7 μg/ml, respectively. [1]Cytotoxic agents remain an important strategy in chemotherapy. In an activity-directed isolation and identification, ansamitocin P-3 was obtained from the active methanol extracts of two mosses. Furthermore, the compound showed great cytotoxicity against several tumor cells. [1]Ansamitocin P-3 is a maytansinoid isolated in very low yield from two members of the moss family Thuidiaceae, Claopodium crispifolium (Hook.) Ren. & Card. and Anomodon attenuatus (Hedw.) Hueb. Further biological evaluation of ansainitocin P-3 showed potent cytotoxicity against the human solid tumor cell line systems A-549 lung carcinoma cells, HT-29 colon adenocarcinoma cells and MCF-7 breast adenocarcinoma cells at ED50 of 4 x 10 -7, 4 x 10 - 7, 2 x 10 -6 μg/ml. respectively. [2]Ansamitocin P-3 exhibited inhibition of cilia regeneration of partially deciliated Tetrahymena. The regeneration of cilia in Tetrahymena was assayed by observing recovery of motility of the deciliated cells which are nonmotile after being deciliated. After 60 min of incubation, more than 95% of partially deciliated Tetrahymena cells in the recovery buffer were fully motile. Ansamitocin P-3 completely inhibited cilia regeneration of Tetrahymena at 1 μM. Moreover, recovery of motility of partially deciliated cells after release from inhibition by 2 μM ansamitocin P-3. [2]
    
    [1]. Suwanborirux, K., et al. "Ansamitocin P-3, a maytansinoid, fromClaopodium crispifolium andAnomodon attenuatus or associated actinomycetes."Experientia 46.1 (1990): 117-120.
    [2]. Tanida, Seiichi, Eiji Higashide, and Masahiko Yoneda. "Inhibition of cilia regeneration of Tetrahymena by ansamitocins, new antitumor antibiotics."Antimicrobial agents and chemotherapy 16.1 (1979): 101.
- Properties
  - Alternative Name
    
    Antibiotic C 15003P3;Maytansinol butyrate;C15003P3
    
    CAS Number
    
    66547-09-9
    
    Molecular Formula
    
    C32H43ClN2O9
    
    Molecular Weight
    
    635.14
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥31.75 mg/mL in DMSO; insoluble in H2O; ≥33.73 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Ansamitocin P-3

Ansamitocin P-3

Background

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