Name: ANQ 11125
Price: 513.00 USD

- Overview
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    Background
    
    ANQ 11125 is a selective antagonist of motilin receptor with pKd of 8.24 [1].
    Motilin receptor is a G protein-coupled receptor for motilin and stimulates contraction of gut smooth muscle.
    ANQ 11125 is a selective motilin receptor antagonist. The affinity of ANQ 11125 for motilin receptor is about 10 times less than motilin [1]. In rabbit antral smooth muscle tissue, ANQ-11125 bound to motilin receptor with pKd value of 8.16. While, ANQ-11125 didn’t induce contractions of rabbit duodenum. ANQ-11125 (10-5 M) induced contractile response by 29% compared to ACh [2].
    
    [1]. Depoortere I, Macielag MJ, Galdes A, et al. Antagonistic properties of [Phe3,Leu13]porcine motilin. Eur J Pharmacol, 1995, 286(3): 241-247.
    [2]. Peeters TL, Depoortere I, Macielag MJ, et al. The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem Biophys Res Commun, 1994, 198(2): 411-416.
- Properties
  - Categories
    
    Motilin receptor antagonist, selective
    
    Alternative Name
    
    (2S,3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S)-17-((Z)-((3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,23S)-23-amino-11,17-dibenzyl-14-((S)-sec-butyl)-1,4,7,10,13,16,19,22-octahydroxy-5-(4-hydroxybenzyl)-8-((R)-1-hydroxyethyl)-20-isopropyl-24-phenyl-3,6,9,12,15
    
    CAS Number
    
    153966-48-4
    
    Molecular Formula
    
    C86H125N19O21
    
    Molecular Weight
    
    1761.05
    
    Appearance
    
    White lyophilised solid
    
    Purity
    
    98.00%
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC[[email protected]]([[email protected]@](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](N)([H])CC1=CC=CC=C1)([H])C(C)C)([H])CC2=CC=CC=C2)([H])/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/C/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](C(O)=O)([H])CC
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

ANQ 11125

ANQ 11125

Background

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