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Overview
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Anisomycin ReadyMade™ Solution is a sterile-filtered (0.2 μm) solution of Anisomycin that has been dissolved in PBS (pH 4.6) at a concentration of 10 mg/ml. Anisomycin is a natural alkaloid anti-protozoal pyrrolidine antibiotic that was discovered in 1954. It can activate signal transduction pathways such as stress-activated protein kinases (SAPK) and MAP kinase. SAPK pathways play a role in a number of diseases including cancer and Alzheimer's disease. The product has been used to study apoptosis, affecting both pro- and anti-apoptotic mechanisms. It stimulates two anti-apoptotic proteins, Akt and Bcl-2, and activates JNKs and P38, which both participate in stress and apoptotic responses. Anisomycin may block the SARS-CoV-2 infection, and it can block the macrophage inflammation which may further inhibit the cytokine storm in COVID-19 disease.
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Background
Anisomycin inhibits protein synthesis and depresses the level of the conventional early mRNAS by inhibiting peptidyl transferase or the 80S ribosome system in eukaryotic systems.
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Overview