Name: Andarine
Price: 276.00 USD

- Overview
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    Background
    
    Andarine (S-4) is a selective inhibitor of AR with Ki value of 4 nM [1].
    Androgen receptor (AR), also known as nuclear receptor subfamily 3, group C, member 4, is a type of nuclear receptor and plays an important role in DNA-binding transcription factor that regulates gene expression [2].
    Andarine is a potent AR inhibitor and has a higher affinity with the reported AR inhibitor S-1, S-2 and S-3. Using a cotransfection system, it was shown that Andarine stimulated AR-mediated transcription as high as 93% at the concentration of 10 nM. [1].
    In male Sprague-Dawley rat model, administration of Andarine resulted in the growth in prostate, seminal vesicles, and levator ani muscle at a dose-dependent manner and promoted their weight being maximally to 33.8, 28.2 and 101% of intact controls, respectively. Further, it was revealed that the ED50 value of Andarine functioning on prostate, seminal vesicles, and levator ani muscle was 0.43±0.01, 0.55±0.02, and 0.14±0.01 mg/day [1].
    
    [1]. Yin, D., et al., Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther, 2003. 304(3): p. 1334-40.
    [2]. Thevis, M., et al., Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls. Rapid Commun Mass Spectrom, 2011. 25(15): p. 2187-95.
- Properties
  - Categories
    
    Androgen receptor agonist
    
    Alternative Name
    
    (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
    
    CAS Number
    
    401900-40-1
    
    Molecular Formula
    
    C19H18F3N3O6
    
    Molecular Weight
    
    441.36
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥21 mg/mL in DMSO; insoluble in H2O; ≥29.15 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O
    
    * For Research Use Only