Amyloid Beta-Peptide (12-28) (human)

- Overview
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    Background
    
    Amyloid beta (Aβ or Abeta) is a peptide of 36–43 amino acids that is processed from the Amyloid precursor protein. While best known as a component of amyloid plaques in association with Alzheimer's disease, evidence has been found that Aβ is a highly multifunctional peptide with significant non-pathological activity(1). Aβ is the main component of deposits found in the brains of patients with Alzheimer's disease. Brain Aβ is elevated in patients with sporadic Alzheimer’s disease. Aβ is the main constituent of brain parenchymal and vascular amyloid, it contributes to cerebrovascular lesions and is neurotoxic(2).
    
    1. Lahiri DK, Maloney B (September 2010). "Beyond the signaling effect role of amyloid–β42 on the processing of AβPP, and its clinical implications". Exp. Neurol. 225 (1): 51–4.
    2. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): 355–8.
- Properties
  - Categories
    
    sequence H2N-VHHQKLVFFAEDVGSNK-OH
    
    Alternative Name
    
    Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys
    
    CAS Number
    
    107015-83-8
    
    Molecular Formula
    
    C89H135N25O25
    
    Molecular Weight
    
    1955.2
    
    Appearance
    
    A solid
    
    Purity
    
    99.46%
    
    Solubility
    
    ≥195.5 mg/mL in DMSO; insoluble in EtOH; ≥59.8 mg/mL in H2O
    
    Storage
    
    Desiccate at -20°C
    
    * For Research Use Only