Name: AM4113
Price: 329.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    AM4113, a pyrazole analog structurally related to SR141716 and AM251, is a novel cannabinoid CB1 neutral antagonist. AM4113 suppressed food intake and food-reinforced behavior in rats.In vitro: AM4113 was able to bind with high affinity to CB1 receptors, exhibiting 100-fold selectivity for CB1 against CB2 receptors. The Ki value for CB1 was 0.897 ± 0.44 nM, while the Ki value for hCB2 was 92 ± 6.9 nM [1].In vivo: In rats, treatment with AM4113 (2.0 and 4.0 mg/kg) attenuated the AM411-induced locomotor suppression and analgesia. In addition, 4.0 mg/kg AM4113 alone significantly suppressed locomotor activity when compared with vehicle. AM4113 dose-dependently decreased lever pressing on an FR1 schedule. AM4113 produced conditioned taste avoidance and suppression of ingestive (hedonic) taste reactivity scores in a dose-dependent manner [1]. AM4113 didn’t induce signs of nausea [1].
- Properties
  - Categories
    
    cannabinoid receptor 1 (CB1)-selective neutral antagonist
    
    Alternative Name
    
    5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
    
    CAS Number
    
    614726-85-1
    
    Molecular Formula
    
    C17H12Cl3N3O
    
    Molecular Weight
    
    380.7
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤0.5mg/ml in ethanol;3mg/ml in DMSO;10mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    ClC1=CC(Cl)=CC=C1N2C(C3=CC=C(Cl)C=C3)=C(C)C(C(N)=O)=N2
    
    * For Research Use Only