Name: Alpha tubulin Monoclonal Antibody
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: Alpha-tubulin [2-4D-8D] monoclonal
  Area: Loading control
  
  Please contact us at for specific academic pricing.
  
  Background
  
  Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Properties
- Host
  
  Mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  Human, Mouse, Rat
  
  Clone
  
  mAb
  
  Storage
  
  Long time storage is recommended at -20°C. Avoid repeated freeze/thaw cycles.
  50mM Tris Glycine, 40% Glycerol (pH7.4). 0.025% ProClin 300 was added as a preservative
  
  Molecular Weight
  
  50
  
  * For research use only.