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Overview
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Alpha-1-antitrypsin (A1AT) is a glycoprotein with a molecular weight of 54 kDa and pI of 4.8. It is a serpine protease inhibitor which acts to limit the amount of cell damage and death at the tissue site. Different isoenzymes exist which together form the protease inhibitor system. Phenotype M is the most common and certain variants (S and Z) are associated with alpha-1-antitrypsin deficiency which can lead to emphysema and liver disease.
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