Name: Alendronate
Price: 185.00 USD

- Overview
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    Background
    
    Alendronate is an inhibitor of bone resorption with IC50 value of 2nM [1].Alendronate is a bisphosphonate. It is developed as a therapeutic agent in many bone disorders such as osteoporosis as well as Paget's disease and tumoral bone disease. Alendronate inhibits the bone resorption through binding to bone mineral and subsequently preventing the osteoclasts from ingesting them. It not only affects the function of osteoclasts but also alter the morphology of the cells. In the in vitro assay, alendronate shows effective antiresorbing potency with IC50 value of 2nM when treated with osteoclast suspension. In organ culture, alendronate inhibits resorption by embryonic long bones and cultured calvaria [1, 2].
    
    [1] Sahni M, Guenther H L, Fleisch H, et al. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. Journal of Clinical Investigation, 1993, 91(5): 2004.
    [2] Bell N H, Johnson R H. Bisphosphonates in the treatment of osteoporosis. Endocrine, 1997, 6(2): 203-206.
- Properties
  - Alternative Name
    
    sodium hydrogen(4-amino-1-hydroxy-1-phosphonobutyl)phosphonate trihydrate
    
    CAS Number
    
    121268-17-5
    
    Molecular Formula
    
    C4H18NNaO10P2
    
    Molecular Weight
    
    325.12
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO; insoluble in EtOH; ≥5.57 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Yanjing Guo, Ruijia Yang, et al. "Metformin Combined with Alendronate Ameliorates Osteoarthritis by Attenuating RANKL-Induced Bone Resorption and Protecting Cartilage Against Degradation." Research Square. rs-1378528/v1.

Alendronate

Alendronate

Background

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