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Overview
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Adenosylhomocysteinase (AHCY) or S-adenosylhomocysteine hydrolase (SAHH) is an enzyme that catalyzes the reversible hydrolysis of S-Adenosyl Homocysteine (SAH) to adenosine and homocysteine (Hcy). In mammals, AHCY is the only enzyme capable of performing this reaction. SAH is the by-product and a potent inhibitor of methyltransferase activity. AHCY deletion is embryonic lethal in many organisms (from plants to mammals). In humans, AHCY deficiency is associated with an incurable rare recessive disorder in methionine metabolism.
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