Name: ACS 67
Price: 241.00 USD

- Overview
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    Background
    
    ACS 67 is an analog of latanoprost acid.
    Latanoprost, an F-series prostaglandin (PG) analog, has been approved for use as an ocular hypotensive drug for the treatment of glaucoma clinically. Latanoprost is an isopropyl ester, a prodrug form which is converted to free latanoprost acid by endogenous esterase enzymes.
    In vitro: In previous study, ACS 67 was found to be able to increase the reduced glutathione levels in normotensive pigmented rabbits significantly after single administration in a dose-dependent manner. Furthermore, in glaucomatous pigmented rabbits after repeated 5-day administration, ACS 67 could also increase the GSH levels when compared with latanoprost. In addition, it was found that ACS 67 could significantly increase the cGMP levels in glaucomatous pigmented rabbits and these data with the combination supported that the increase of cGMP was due to the sulfurated moiety of ACS 67. Moreover, the tolerability was measured in New Zealand albino rabbits at three different concentrations of ACS 67, and results indicated that ACS 67 was very well tolerated in Draize test [1].
    In vivo: So far, there in no animal in vivo data reported.
    Clinical trial: Up to now, ACS 67 is still in the preclinical development stage.
    
    Reference:[1] E. Perrino, C. Uliva, C. Lanzi, et al. New prostaglandin derivative for glaucoma treatment. Bioorganic & Medicinal Chemistry Letters 19, 1639-1642 (2009).
- Properties
  - Categories
    
    analog of latanoprost (free acid), prostaglandin (PG) analog
    
    Alternative Name
    
    7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, 5Z-heptenoic acid
    
    CAS Number
    
    1088434-86-9
    
    Molecular Formula
    
    C32H38O5S3
    
    Molecular Weight
    
    598.8
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≤2mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]@H]1[[email protected]](C/C=C\CCCC(OC2=CC=C(C3=CC(SS3)=S)C=C2)=O)[[email protected]@H](CC[[email protected]@H](O)CCC4=CC=CC=C4)[[email protected]](O)C1
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

ACS 67

ACS 67

Background

Documents

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