Name: Ubiquitin Isopeptidase Inhibitor I
Price: 274.00 USD

- Overview
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    Background
    
    IC50: ~30 μMUbiquitin Isopeptidase Inhibitor I is a ubiquitin isopeptidase inhibitor.Conjugation or deconjugation of ubiquitin or ubiquitin-like proteins to or from cellular proteins is a multifaceted and universal ways of regulating cellular physiology, controlling the lifetime, localization, and activity of various key proteins.In vitro: Ubiquitin Isopeptidase Inhibitor I targeted the ubiquitinproteasome system via inhibiting the ubiquitin isopeptidases. Ubiquitin Isopeptidase Inhibitor I could induce a rather unique apoptotic pathway, including a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. Moreover, the treatment of Ubiquitin Isopeptidase Inhibitor I to cell extracts obtained from E1A cells did not inhibit the proteolytic activity of the proteasome, whereas MG-132 potently inhibited the cleavage of the LLVY-AMC substrate. In addition, Noxa induction by Ubiquitin Isopeptidase Inhibitor I could be inhibited by the specific RNAi oligos efficiently. When apoptosis was scored, it was found that down-regulation of Noxa was able to inhibit but did not suppress apoptosis and caspase activation in response to Ubiquitin Isopeptidase Inhibitor I treatment [1]. In vivo: So far, there is no animal in vivo data reported. Clinical trial: Up to now, Ubiquitin Isopeptidase Inhibitor I is still in the preclinical development stage.
- Properties
  - Alternative Name
    
    NSC 144303; tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide
    
    CAS Number
    
    108477-18-5
    
    Molecular Formula
    
    C19H14N2O7S
    
    Molecular Weight
    
    414.4
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Ubiquitin Isopeptidase Inhibitor I

Ubiquitin Isopeptidase Inhibitor I

Background

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