Name: Ac-Endothelin-1 (16-21), human
Price: 148.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues, including the heart, the kidney, and the central nervous system.
    At the cellular level, the effects of ET-1 appear to be mediated by two speciﬁc receptor subtypes termed ETA and ETB, both of which are functionally coupled to phospholipase C (PLC).
    The C-terminal fragment , which is a highly conserved sequence in the peptides of the ET family, has been shown to discriminate between the two ET receptor subtypes termed ETA and ETB since it activates only the latter ones.
    
    1. Rubanyi, G. M., and M. A. Polokoff. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46: 325–415, 1994
    2. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375–411.
    3. PM Vanhoutte Endothelin-1. A matter of life and breath, Nature, 368 (1994), pp. 693–694
- Properties
  - Categories
    
    ETA/ETB agonist, vasoconstrictor
    
    Alternative Name
    
    Ac-His-Leu-Asp-Ile-Ile-Trp-OH
    
    Molecular Formula
    
    C41H59N9O10
    
    Molecular Weight
    
    837.96
    
    Appearance
    
    A solid
    
    Purity
    
    98.49%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥83.8 mg/mL in DMSO with gentle warming
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CC(O)=O)C(N[[email protected]@H]([[email protected]](C)CC)C(N[[email protected]@H]([[email protected]](C)CC)C(N[[email protected]@H](CC1=CC(C=CC=C2)=C2N1)C(O)=O)=O)=O)=O)=O)[[email protected]](CC3=CNC=N3)NC(C)=O
    
    * For Research Use Only