6-SIMA phosphoramidite

Catalog Number:
CAL1137339MET
Mfr. No.:
303-55
Price:
$1,170
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      • Overview
        • SIMA is a full spectral analog of HEX in all fluorescent applications, but has significantly improved stability. It has a higher quantum yield and molecular extinction than HEX. SIMA is also more versatile in oligo synthesis especially due to improved stability during deprotection and simple purification of labeled oligos

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      • Properties
        • Categories
          SIMA Phosphoramidites
          Alternative Name
          [(3’,6’-dipivaloyl-2’,7’-diphenyl-4,7-dichlorofluoresceinyl)-6-carboxamidohexyl]-1-O- (2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
          Molecular Formula
          C58H64Cl2N3O10P
          Molecular Weight
          1065
          Purity
          > 95%
          Other Properties
          Coupling: No changes needed from standard method recommended by synthesizer manufacturer.
          Diluent: Anhydrous Acetonitrile
          Deprotection: No changes needed from standard method recommended by synthesizer manufacturer. SIMA labeled oligos are stable at 55°C in ammonium hydroxide (up to 6-8 hours) and can be deprotected with AMA.
          Stability in Solution: 2-3 days, <90% efficient after 4 days
          Storage
          Freezer storage, -10 to -30°C, dry.
          Note
          Store labeled oligo in the dark, either dry or in a neutral aqueous media at -20°C. Do not store crude fluorescently labeled oligonucleotides in ammonia.

          * For research use only

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