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Overview
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3'-Amino-2',3' dideoxynucleosides are synthesized via biotransformation and used as initial compounds for preparation of corresponding 3'-Amino-2',3'-Dideoxynucleoside-5'-CE Phosphoramidites. The latter are building blocks for the assembly of Oligonucleotide N3' -> P5' phosphoramidates, that form extremely stable double and triple stranded complexes with DNA and RNA under physiological conditions and appear to be efficient telomerase inhibitors and antisense agents.
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Overview