2'-C-Methylcytidine

- Overview
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    Background
    
    2’-C-Methylcytidine has been shown to be a small-molecule inhibitor of viral nucleoside polymerase. In hepatitis C virus, it inhibits HCV NS5B RNA polymerase.
    In studies with foot-and-mouth disease, experiments suggest that the compound interacts with the viral replication that coincides with the onset of intracellular viral RNA synthesis.
- Properties
  - CAS Number
    
    20724-73-6
    
    Molecular Formula
    
    C10H15N3O5
    
    Molecular Weight
    
    257.24
    
    Appearance
    
    Off-white powder
    
    Solubility
    
    Sparingly soluble in water
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: 2’-C-Methylcytidine can be used for multiple viruses including hepatitis C virus (HCV), Norwalk virus, and bovine pestivirus. It is also effective for three flaviviruses including yellow fever virus, West Nile virus, and dengue-2 virus. It has in vitro activity against coxsackievirus causing hand-foot-and-mouth disease and yellow fever virus.
    
    Microbiology Applications: NM 283 is an efficient prodrug of 2’-C-methylcytidine. It is an 3’-O-L-valinyl ester derivative. It is a promising antiviral for HCV infection (Pierra et al, 2011).
    Studies in a cell-based replicon assay indicated that several of the phosphoaramidates including NM 283 demonstrated a 10- to 200-fold potency due to higher levels of 2’-C-methylcytidine triphosphate in the cells. These prodrugs are converted to the triphosphate in hepatocytes (Gardelli et al, 2009).