15-acetoxy Scirpenol

- Overview
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    Background
    
    15-acetoxy Scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the Fusarium genus [1]. 15-acetoxy Scirpenol could induce apoptotic cell death in human Jurkat T cells. Mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus Fusarium. Acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy Scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). The 50% inhibitory concentration (IC50) values of 15-acetoxy Scirpenol was 16.1 ng/ml [2]. In the Jurkat T cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-MAS), the populations of externalized PS-positive and PI-negative cells were 32.0% [2].
    
    [1] Peraica M, Radic B, Lucic A, et al. Toxic effects of mycotoxins in humans[J]. Bulletin of the World Health Organization, 1999, 77(9): 754-766.
    [2] Lee D H, Park T, Kim H W. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins[J]. Biological and Pharmaceutical Bulletin, 2006, 29(4): 648-654.
- Properties
  - Categories
    
    mycotoxin that induce apoptotic cell death
    
    Alternative Name
    
    4-Deacetylanguidin,NSC 267030; 12,13-epoxy-trichothec-9-ene-3α,4β,15-triol, 15-acetate
    
    CAS Number
    
    2623-22-5
    
    Molecular Formula
    
    C17H24O6
    
    Molecular Weight
    
    324.4
    
    Appearance
    
    A powder
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤10mg/ml in methanol;10mg/ml in dichloromethane
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=C[[email protected]]2([H])[[email protected]]([[email protected]]([[email protected]](O)[[email protected]]3O)(C)[[email protected]@]4(OC4)[[email protected]]3([H])O2)(COC(C)=O)CC1
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

15-acetoxy Scirpenol

Background

Documents

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