10Panx

- Overview
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    Background
    
    10Panx is a mimetic inhibitory peptide of panx1, which is a mammalian protein ectopically expressed to function as a hemi-channel, that readily and reversibly inhibits the panx1 currents. 10Panx has attracted increasing attention as it allows scientists readily and reliably to examine inhibition of panx1 in cells where efficient and consistent delivery of siRNA is highly difficult. According to results of multiple previous studies, 10Panx selectively inhibits P2X7R-induced dye uptake without altering other aspects of R2X7R activation and ATP-evoked membrane currents, constitutive dye-uptake and hemichannel-like currents that are induced by the overexpression of panx1, and ATP-mediated IL-1β release.
- Properties
  - Alternative Name
    
    10Panx
    
    CAS Number
    
    955091-53-9
    
    Molecular Formula
    
    C58H79N15O16
    
    Molecular Weight
    
    1242.37
    
    Appearance
    
    A solid
    
    Purity
    
    99.29%
    
    Solubility
    
    ≥124.2 mg/mL in DMSO; insoluble in EtOH; ≥4.26 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Shuzhen Dong, Kai Zhang, et al. "Carbenoxolone has the potential to ameliorate acute incision pain in rats." Mol Med Rep. 2021 Jul;24(1):520. PMID:34013377
    2. Fan J, Chen Y, et al. "Multi-walled carbon nanotubes induce IL-1β secretion by activating hemichannels-mediated ATP release in THP-1 macrophages." Nanotoxicology. 2020;1-18. PMID:32538272
    3. Wang Q, Li M, et al. "Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer." Theranostics. 2020;10(5):2141–2157. PMID:32089737
    4. Gao J, Zhang T, et al. "The F0F1 ATP synthase regulates human neutrophil migration through cytoplasmic proton extrusion coupled with ATP generation." Mol Immunol. 2017 Aug 23;90:219-226. PMID:28843171

10Panx

Background

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