Name: ZJ 43
Price: 705.00 USD

- Overview
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    Background
    
    IC50: 2.4 nMZJ-43 is a N-acetylaspartylglutamate (NAAG) peptidase inhibitor. The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) is reported to act as an agonist at group II metabotropic glutamate receptors. NAAG is inactivated by extracellular peptidase activity leading to yielding glutamate and N-acetylaspartate.In vitro: As a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III) with Kivalues of 0.8 and 23 nM respectively, ZJ-43 inhibited the hydrolysis of NAAG via indirect interactions with NMDA or metabotropic glutamate receptors [1]. In vivo: Intravenous injection of ZJ-43 coiuld suppress both phases of the agitation behaviour induced by paw formalin injection in the rat neuropathic pain model. Moreover, intravenous administration of ZJ-43 attenuated the level of mechanical allodynia induced by the nerve ligation. These effects of ZJ-43 in both the formalin test and the partial sciatic nerve ligation model were completely antagonized by pretreatment with LY-341495, which was a highly selective group II mGluR antagonist [1]. Clinical trial: N/A
- Properties
  - Alternative Name
    
    (2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid
    
    CAS Number
    
    723331-20-2
    
    Molecular Formula
    
    C12H20N2O7
    
    Molecular Weight
    
    304.3
    
    Appearance
    
    White solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <30.43mg/ml in H2O; <30.43mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Wenlan Zhou, Shun Huang, et al. "Automatic radiosynthesis and preclinical evaluation of 18F-AlF-PSMA-NF as a potential PET probe for prostate cancer imaging." Amino Acids. 2021 Jun;53(6):929-938. PMID:34014365

ZJ 43

ZJ 43

Background

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