Name: ZIP
Price: 298.00 USD

- Overview
  - Protein kinase Mζ inhibitor.
    ZIP, or Zeta inhibitory peptide, is a cell permeable pseudo-substrate inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ induced synaptic potentiation in hippocampal slices in vitro and is widely used to investigate memory in a variety of learning tasks, including spatial sensitization, pain sensitization, fear-associated memories, conditioned taste aversion and development of locomotor sensitization in rodents. However, LTP and LTM are unaffected in both constitutive and conditional PKMζ knock-out mice, yet both are still impaired by ZIP application, suggesting another mechanism of action which may involve ionotropic glutamate AMPA receptors (AMPARs).
    
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- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    z-Pseudosubstrate inhibitory peptide, Zeta inhibitory peptide, myristoylated
    
    Molecular Formula
    
    C90H154N30O17
    
    Molecular Weight
    
    1928.4
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble to 1 mg/ml in water
    
    Other Properties
    
    Sequence: Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH,Myr-SIYRRGARRWRKL
    Modification: N terminal myristoyl
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

ZIP

ZIP

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