Name: Zidovudine
Price: 180.00 USD

- Overview
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    Background
    
    Zidovudine is an inhibitor of the reverse transcriptase of HIV-1[1].
    Zidovudine is the first effective agent for the management of HIV-1 infection and is approved by FDA as a drug for AIDs in 1987. As a nucleoside analogue, zidovudine inhibits the activity of the reverse transcriptase with its triphosphate structure. In the in vitro studies, zidovudine shows strong inhibition of HIV-1 replication and the cytopathic effect of the virus. The addition of 5μM and 10μM zidovudine completely protects TM3 cells (a normal IL-2-dependent helper/inducer T-cell clone) and ATH8 cells against the cytopathic effect of HIV. It exhibits complete inhibition of reverse transcriptase at concentration up to 0.5μM. However, the resistance of zidovudine has been found in vitro and in vivo since 1989 [1, 2].
    
    [1] Mitsuya H, Weinhold K J, Furman P A, et al. 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proceedings of the National Academy of Sciences, 1985, 82(20): 7096-7100.
    [2] McLeod G X, Hammer S M. Zidovudine: five years later. Annals of internal medicine, 1992, 117(6): 487-501.
- Properties
  - Alternative Name
    
    1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
    
    CAS Number
    
    30516-87-1
    
    Molecular Formula
    
    C10H13N5O4
    
    Molecular Weight
    
    267.24
    
    Appearance
    
    A solid
    
    Purity
    
    99.81%
    
    Solubility
    
    ≥17.6 mg/mL in H2O with gentle warming and ultrasonic; ≥26.5 mg/mL in EtOH with gentle warming; ≥8.35 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Zidovudine

Zidovudine

Background

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