Name: Z-YVAD-FMK
Price: 1092.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.In Caco-2 cells, Z-YVAD-FMK significantly decreased the growth inhibition induced by butyrate. Complete abrogation of butyrate’s effect occurred at an inhibitor concentration of 100 μmol/L. It is indicated that caspase-1 inhibitor significantly alters the caspase cascade, diminishing the butyrate-induced apoptotic effect [1]. After treated with Alum reflected caspase-1 activation, IL-1-release in cells was blocked by Z-YVAD-FMK. This effect was observed even in MyD88-deficient bone marrow DC [2].
    
    1.Avivi-Green C, Polak-Charcon S, Madar Z, et al. Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr. 2002 Jul;132(7):1812-8.
    2.Li H, Nookala S, Re F. Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol. 2007 Apr 15;178(8):5271-6.
- Properties
  - Alternative Name
    
    (8S,11S,14S)-methyl 14-(2-fluoroacetyl)-5-(4-hydroxybenzyl)-8-isopropyl-11-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
    
    Molecular Formula
    
    C31H39FN4O9
    
    Molecular Weight
    
    630.66
    
    Purity
    
    99.33%
    
    Solubility
    
    ≥31.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Shouwen Chen, Peng Jin, et al. "Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation." Dev Comp Immunol. 2021 Aug;121:104078. PMID:33794278
    2. Peng Zhang, Boyao Lu, et al. "Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation." J Periodontal Res. 2021 Aug;56(4):667-678. PMID:33650689
    3. Kai J, Yang X, et al. "Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease." Free Radic Biol Med. 2020;153:89-102. PMID:32289481
    4. Ding H, Li Y, et al. "Treatment with 7% and 10% CO2 enhanced expression of IL-1β, TNF-α, and IL-6 in hypoxic cultures of human whole blood." J Int Med Res. 2020;48(4):300060520912105. PMID:32264730
    5. Wang X, Li H, et al. "The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy." Cell Biol Toxicol. 2020;10.1007/s10565-020-09514-8. PMID:31993881
    6. Hodges AL, Kempen CG, et al. "TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin." Toxins (Basel). 2019 Aug 1;11(8). pii: E450. PMID:31374990
    7. Dong X, Zheng Z, et al. "ACPAs promote IL-1βproduction in rheumatoid arthritis by activating the NLRP3 inflammasome." Cell Mol Immunol. 2019 Mar 25. PMID:30911117
    8. Chou X, Ding F, et al. "Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells. Arch Toxicol." 2019 Feb 22. PMID:30796460
    9. Hua S, Ma M, et al. "Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis." Int Immunopharmacol. 2019 Mar;68:145-155. PMID:30634142
    10. Yang D, Zheng X, et al. "Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish." Nat Commun. 2018 Aug 3;9(1):3052. PMID:30076291
    11. Fanfan Xu, Xinghua Qiu, et al. "Effects on IL-1b signaling activation induced by water and organic extracts of fine particulate matter (PM2.5) in vitro" Environmental Pollution 237 (2018) 592e600. PMID:29525626
    12. Kalantari P, Morales Y, Met al. "CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology." Cell Rep. 2018 Jan 30;22(5):1288-1300. PMID:29386115
    13. Ding HG, Deng YY, et al. "Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats. "J Neuroinflammation. 2018 Jan 5;15(1):4. PMID:29304864

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