Name: YM155
Price: 206.00 USD

- Overview
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    Background
    
    Sepantronium bromide, also known as YM155, is a novel small-molecule suppressant of surviving, the smallest member of inhibitor of apoptosis (IAP) gene family. It exhibits a potent suppressive activity against survivin but has little effect on expression levels of other IAP family members or B-cell lymphoma 2 (BCL-2) related proteins. YM155 also suppresses proliferation in a broad range of human cancer cell lines, induces tumor regression in non-small cell lung cancer (NSCLC), melanoma, bladder, aggressive non-Hodgkin lymphoma, and breast cancer xenograft models, reduces spontaneous metastases, and significantly prolongs the survival of animal harboring established metastatic tumors derived from a human triple-negative breast cancer (TNBC) cell lines.
- Properties
  - Categories
    
    Survivin suppressant, apoptosis inhibitor
    
    Alternative Name
    
    Sepantronium bromide,YM-155; 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide
    
    CAS Number
    
    781661-94-7
    
    Molecular Formula
    
    C20H19BrN4O3
    
    Molecular Weight
    
    443.3
    
    Appearance
    
    A solid
    
    Purity
    
    98.92%
    
    Solubility
    
    ≥22.15 mg/mL in DMSO; ≥13.49 mg/mL in EtOH with ultrasonic; ≥96.2 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
    
    * For Research Use Only
- Reference
  - 1. Hou LJ, Huang XX, et al. "YM155 enhances docetaxel efficacy in ovarian cancer." Am J Transl Res. 2018 Mar 15;10(3):696-708. PMID:29636860
    2. GAO, JH, et al. "YM155 inhibits tumor growth and enhances chemosensitivity to cisplatin in osteosarcoma." Eur Rev Med Pharmacol Sci 19.11 (2015): 2062-2069.