Name: YC 1
Price: 228.00 USD

- Overview
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    Background
    
    IC50: 1.2 M for hypoxia-induced HIF-1 transcriptional activity YC-1 is a novel anticancer drug initially developed as an inhibitor of HIF-1α. Hypoxia-inducible factor-1α (HIF-1α) is a basic helix-loop-helix transcription factor regulating expression of VEGF and other genes which modulate survival, growth and metastasis of tumor cells under conditions of hypoxia.In vitro: YC-1 could inhibit platelet aggregation and vascular contraction via activating soluble guanylyl cyclase and was originally developed as a potential therapeutic agent for circulation disorders. YC-1 completely inhibited HIF-1α expression at the post-transcriptional level and consequently blocked the transcription factor activity of HIF-1 in hepatoma cells under hypoxic conditions, indicating that such effects of YC-1 were likely to be associated with the oxygen-sensing pathway but not with the soluble guanylyl cyclase activation [1]. In vivo: Compared with tumors from vehicle-treated mice, tumors from YC-1-treated group were found to be statistically smaller and less vascularized. In addition, tumors from YC-1-treated group expressed lower levels of HIF-1α as well as HIF-1-inducible genes, regardless of tumor type [1]. Clinical trial: N/A
    
    Reference:[1] Yeo EJ,Chun YS,Cho YS,Kim J,Lee JC,Kim MS,Park JW. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst.2003 Apr 2;95(7):516-25.
- Properties
  - Categories
    
    soluble guanylyl cyclase (sGC) activator
    
    Alternative Name
    
    (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol
    
    CAS Number
    
    170632-47-0
    
    Molecular Formula
    
    C19H16N2O2
    
    Molecular Weight
    
    304.34
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥30.4 mg/mL in DMSO; insoluble in H2O; ≥16.2 mg/mL in EtOH
    
    Storage
    
    Store at RT
    
    SMILES
    
    OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=CC=CC=C42)O1
    
    * For Research Use Only
- Reference
  - 1. Zhang Z, Ran C, et al. "Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish." Commun Biol. 2019 Jul 25;2:274. PMID:31372513