Name: Y-39983 dihydrochloride
Price: 326.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Y-39983 dihydrochloride is a novel and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK [1].Y-39983 dihydrochloride has shown a selective inhibitor of Rho-associated coiled coil-forming protein kinase( ROCK ) with IC50 values of 3.6nM, 0.42μM and 0.81μM for ROCK, PKC and CaMKII, respectively [1]. Apart from these, Y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. In addition, Y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. Moreover, Y-39983 lowered the intraocular pressure ( IOP) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].
    
    [1] Tokushige H1, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M, Tanihara H. Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3216-22.
    [2] Watabe H1, Abe S, Yoshitomi T. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries. Jpn J Ophthalmol. 2011 Jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. Epub 2011 Jun 11.
- Properties
  - Alternative Name
    
    4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide;dihydrochloride
    
    CAS Number
    
    173897-44-4
    
    Molecular Formula
    
    C16H18Cl2N4O
    
    Molecular Weight
    
    353.25
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥18.05 mg/mL in DMSO; ≥6.34 mg/mL in EtOH with ultrasonic; ≥26.5 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Y-39983 dihydrochloride

Y-39983 dihydrochloride

Background

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