Name: XBP1 Antibody
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: XBP1
  Area: ER stress
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Properties
- Host
  
  Rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  Human, Mouse, Rat
  
  Clone
  
  pAb
  
  Immunogen
  
  Synthetic peptide / encompassing a sequence within the N-terminus region.
  
  Storage
  
  Store at +4°C for short term storage. Long time storage is recommended at -20°C
  100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
  
  Molecular Weight
  
  60-80
  
  * For research use only.