Name: WZ811
Price: 220.00 USD

- Overview
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    Background
    
    WZ811 is a small molecule antagonist of CXC chemokine receptor 4 (CXCR4) [1].WZ811 is synthesized with two aromatic amine moieties. It is found to effectively inhibit TN14003 binding to CXCR4 with EC50 value of 0.3nM at first. And then WZ811 is found to have ability in counteracting SDF-1 function and blocking CXCR4/SDF-1-mediated signaling. In the cAMP assay, WZ811 reduces the effect on cAMP caused by 150ng/ml SDF-1 significantly. It also blocks the SDF-1 induced Matrigel invasion with EC50 value of 5.2nM. Since CXCR4 is involved in the pathogeneses of a wide range of infectious, inflammatory and other diseases, WZ811 is developed for the treatment of various CXCR4-related diseases. It is reported to have weak anti-HIV activity in cell culture [1, 2].
    
    [1] Zhan W, Liang Z, Zhu A, et al. Discovery of small molecule CXCR4 antagonists. Journal of medicinal chemistry, 2007, 50(23): 5655-5664.
    [2] Choi W T, Duggineni S, Xu Y, et al. Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4). Journal of medicinal chemistry, 2011, 55(3): 977-994.
- Properties
  - Categories
    
    Competitive CXCR4 antagonist, highly potent
    
    Alternative Name
    
    N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine
    
    CAS Number
    
    55778-02-4
    
    Molecular Formula
    
    C18H18N4
    
    Molecular Weight
    
    290.36
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥15.02 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1=CC=NC(=C1)NCC2=CC=C(C=C2)CNC3=CC=CC=N3
    
    * For Research Use Only