Name: WEHI-539 hydrochloride
Price: 436.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    WEHI-539 hydrochloride is a small-molecule inhibitor of BCL XL with IC50 value of 1.1 nM [1].
    WEHI-539 was designed as a BCL-XL inhibitor with high affinity. It interacted with the binding groove of BCL-XL with Kd value of 0.6 nM. In MEF cells lacking MCL-1, WEHI-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome c and caspase-3 processing. In BCL-XL overexpressed MEF cells, WEHI-539 showed EC50 value of 0.48 μM. WEHI-539 also significantly induced apoptosis of the platelets purified from mice. Besides that, WEHI-539 cannot kill MEF cells lacking BAK because the cell death mediator BAK is regulated by BCL-XL and MCL-1. [1].
- Properties
  - Alternative Name
    
    (E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
    
    CAS Number
    
    2070018-33-4
    
    Molecular Formula
    
    C31H30ClN5O3S2
    
    Molecular Weight
    
    620.18
    
    Appearance
    
    A solid
    
    Purity
    
    99.15%
    
    Solubility
    
    ≥28.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Kim YJ, Tsang T, et al. "Inhibition of BCL2 family members increases the efficacy of copper chelation in BRAFV600E-driven melanoma." Cancer Res. 2020;canres.1784.2019. PMID:32005716
    2. Rose JC, Dieter EM, et al. "Examining RAS pathway rewiring with a chemically inducible activator of RAS." Small GTPases. 2018 Apr 10:1-8. PMID:29634387

WEHI-539 hydrochloride

WEHI-539 hydrochloride

Background

We Also Recommend

IOWH-032

LY2603618

RN486