Walnut Antigen

Walnut Antigen is a specific substance derived from walnut proteins used in allergy testing and diagnosis. Walnuts are a common allergen that can cause allergic reactions in susceptible individuals.
The Walnut Antigen is extracted and purified from walnut proteins and is utilized to identify individuals who are allergic to walnuts. It is typically used in skin prick tests or blood tests to determine allergic responses. By measuring specific antibodies in the blood or conducting skin prick tests, healthcare professionals can accurately diagnose walnut allergies and provide appropriate management and treatment plans.

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Background

Walnut allergy is primarily an IgE-mediated immediate hypersensitivity reaction. Walnut allergens identified using sera from walnut-allergic patients include Jug r 1, Jug r 2, Jug r 3, and Jug r 4. Among these, Jug r 1 is recognized by sera from more than 80% of walnut-allergic patients and is considered the major allergenic protein in walnuts.

IgE binds to Fc receptors on the surface of effector cells such as mast cells. Upon re-exposure to the allergen, cross-linking occurs between the allergen and IgE antibodies on the mast cell surface, triggering degranulation and the release of inflammatory mediators, which subsequently lead to clinical symptoms.