VSV-G Peptide

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Background

VSV-G , a vesicular stomatitis virus G (VSV-G) protein fragment. VSV-G protein is commonly used in biomedical research to pseudotype retroviral and lentiviral vectors, conveying the ability to transduce a broad range of mammalian cell types with genes of interest. [1] The VSIV G protein has also been used in cytological studies of trafficking in the endomembrane system. Immunoelectron microscopy suggests that VSIV G protein moves from cis to trans Golgi bodies without being transported between them in vesicles, supporting the cisternal maturation model of Golgi trafficking. [2]

1. Cronin J, Zhang XY, Reiser J (2005). "Altering the tropism of lentiviral vectors through pseudotyping". Curr Gene Ther 5 (4): 387–98.
2. Mironov AA, Beznoussenko GV, Nicoziani P, Martella O, Trucco A, Kweon H, Giandomenico DD, Polishchuk RS, Fusella A, Lupetti P, Berger EG, Geerts WJC, Koster AJ, Burger KNJ, Luini A (2001). "Small cargo proteins and large aggregates can traverse the Golgi by a common mechanism without leaving the lumen of cisternae". JCB 155 (7): 1225–38.