-
-
Overview
-
Vitamin D binding protein (VDBP, also known as group-specific component / Gc protein) is a multifunctional serum protein which is formed in the liver. High estrogen levels, caused e. g. by pregnancy or hormonal birth control, stimulate its synthesis. VDBP can be found in plasma, ascites, liquor, urine and at the surface of various cell types.
In the blood, VDBP binds the bigger part of the circulating 25-OH vitamin D and brings it to the kidneys, where it is transformed into the hormone 1,25-(OH)2 vitamin D. VDBP binds to monomeric actin at the ratio of 1:1 and is a precursor of the immunomodulating protein Gc protein-derived macrophage activating factor (Gc-MAF).
Research area interests include sepsis, trauma, organ failure, Nephritic syndrome, and Tumors.Please contact us at for specific academic pricing.
-
- Properties
- Applications
-
Overview