Verapamil HCl

- Overview
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    Background
    
    Verapamil is an L-type calcium channel blocker of thephenylalkylamine class.
- Properties
  - Categories
    
    L-type calcium channel blocker
    
    Alternative Name
    
    2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
    
    CAS Number
    
    152-11-4
    
    Molecular Formula
    
    C27H39ClN2O4
    
    Molecular Weight
    
    491.06
    
    Purity
    
    99.90%
    
    Solubility
    
    ≥14.45 mg/mL in DMSO; ≥6.41 mg/mL in H2O with ultrasonic; ≥8.95 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
    
    * For Research Use Only
- Reference
  - 1. Liying Chen, Zhi Chen, et al. "Study on mechanism of elemene reversing tumor multidrug resistance based on luminescence pharmacokinetics in tumor cells in vitro and in vivo." RSC Adv. 2020, 10, 34928-34937.
    2. Li Y, Cao F, et al. "Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages." J Exp Clin Cancer Res. 2018 Oct 29;37(1):259. PMID:30373678