Name: Varenicline Hydrochloride
Price: 300.00 USD

- Overview
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    Background
    
    Varenicline Hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].Varenicline Hydrochloride has been reported to potently inhibit nAChR binding with the Ki values of 0.12±0.02 nM and 0.14±0.01 nM for α6β2* nAChR and α4β2* nAChR, respectively in rat striatum, 0.13±0.01 nM and 0.19±0.11 nM forα6β2* nAChR and α4β2* nAChR, respectively in monkey striatum. In addition, varenicline Hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nAChRs compared with nicotine with the EC50 values of 0.007 and 0.086μM, respectively in rat striatum [1].
    
    [1] Bordia T1, Hrachova M, Chin M, McIntosh JM, Quik M. Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34. doi: 10.1124/jpet.112.194852. Epub 2012 May 1.
- Properties
  - Categories
    
    α4β2 nicotinic receptor agonist
    
    Alternative Name
    
    (6R)-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride
    
    CAS Number
    
    230615-23-3
    
    Molecular Formula
    
    C13H14ClN3
    
    Molecular Weight
    
    247.72
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    Cl[H].[H]C1(C([H])([H])N([H])C2([H])[H])C([H])([H])[[email protected]]2([H])C3=C([H])C4=NC([H])=C([H])N=C4C([H])=C13
    
    * For Research Use Only