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Overview
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UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.
UCN-01 is soluble in ethanol, methanol, DMF and DMSO.Please contact us at for specific academic pricing.
Background
UCN-01 inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis.
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- Properties
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Overview
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