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Overview
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Background
Triacsin C is a potent inhibitor of long chain acyl-CoA synthetase, with an IC50 value of 6.3 μM in Raji cell membrane fraction. Long chain acyl-CoA synthetase is essential for catalyzing the conversion of free fatty acids to acyl-CoAs. Inhibition of acyl-CoA synthetase has been shown to interfere lipid synthesis as well as cell proliferation in Raji lymphoma cells. Triacsin C also induces apoptosis in many cancer cell lines, such as human lung cancer cells. In addition, Triacsin C has been found to be highly effective against rotavirus replication.
1. Tomoda H, Igarashi K, Cyong JC, et al. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Journal of Biological Chemistry, 1991, 266(7): 4214-4219.
2. Mashima T, Oh-hara T, Sato S, et al. p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. Journal of the National Cancer Institute, 2005, 97(10): 765-777.
3. Kim Y, George D, Prior AM, et al. Novel triacsin C analogs as potential antivirals against rotavirus infections. European Journal of Medicinal Chemistry, 2012, 50: 311-318.
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