Name: Torin 2
Price: 294.00 USD

- Overview
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    Background
    
    Torin2 is a potent, selective and orally available inhibitor of mTOR with EC50 value of 0.25nM [1].Torin2 is a highly potent and selective mTOR inhibitor. It is easier to produce than its lead compound Torin1 and displays improved pharmacokinetic properties. Torin2 is predicted to engage in hydrogen bonds with V2240 and Y2225 of a homology model of mTOR. It also form two hydrogen bonds between the aniline amino group of it with D2195 and D2357, making it more potent than Torin1. Besides that, Torin2 shows excellent overall selectivity and has strong binding to mTOR, CSNK1E, several PI3Ks, CSF1R and MKNK2. Torin2 exerts 800-fold cellular selectivity relative to inhibition of PI3K and other protein kinases. Moreover, Torin2 shows good bioavailability and exposure in vivo [1].
    
    [1] Liu Q, Wang J, Kang S A, et al. Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl) phenyl) benzo [h][1, 6] naphthyridin-2 (1 H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer. Journal of medicinal chemistry, 2011, 54(5): 1473-1480.
- Properties
  - Alternative Name
    
    9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one
    
    CAS Number
    
    1223001-51-1
    
    Molecular Formula
    
    C24H15F3N4O
    
    Molecular Weight
    
    432.41
    
    Appearance
    
    A solid
    
    Purity
    
    99.37%
    
    Solubility
    
    ≥21.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Ming Liu, Jinyi Zhang, et al. "WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity." Science. 2021 Mar 26;371(6536):eaaz4544. PMID:33766857
    2. Tariqul Islam AFM, Scavello M, et al. "Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors." Mol Cell Biochem. 2019 Jul;457(1-2):157-168. PMID:30879206

Torin 2

Torin 2

Background

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