Name: TNF-Alpha, Soluble (human) (rec.)
Price: Inquiry

- Overview
  - Binds to human and mouse TNF-R1. Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-Alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-Alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-Alpha (MultimericTNF-Alpha). Since the MultimericTNF-Alpha mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-Alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-Alpha or MultimericTNF-Alpha can be used.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    Tumor Necrosis Factor Ligand Superfamily Member 2; Cachectin
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Reactivity
    
    Mouse; Human
    
    Purification
    
    >=95% (SDS-PAGE)
    
    Formulation
    
    Reconstitution 10 µg size: Reconstitute with 100 µl sterile water. 50 µg size: Reconstitute with 50 µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions. Concentration 10 µg size: 0.1 mg/ml after reconstitution. 50 µg size: 1 mg/ml after reconstitution. Formulation: Lyophilized. Contains PBS.
    
    Storage
    
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
    
    Endotoxin
    
    <0.01EU/μg purified protein (LAL test; Lonza).
    
    Activity
    
    Induces cell death at a concentration range of 0.01-10ng/ml (ED50= 0.05ng/ml or 2 x 10E7 Units/mg; WEHI 164 cells).
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

TNF-Alpha, Soluble (human) (rec.)

TNF-Alpha, Soluble (human) (rec.)

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