Name: Tissue Factor / CD142 (HiLyte Fluor647 Conjugated) Antibody
Price: Inquiry

Overview
- Sensitivity: Endogenous
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
Properties
- Host
  
  Rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  Human
  
  Immunogen
  
  Synthetic peptide
  
  Conjugate
  
  HiLyte Fluor647
  
  Storage
  
  PBS (pH 7.4), 0.2% BSA, 0.1% Gelatin, 0.1% NaN3 was added as a preservative
  This product is stable for 12 months when stored undiluted between 2°C and 8°C, protected from prolonged exposure to light. Do not freeze.
  
  * For research use only.